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ПУБЛИКАЦИИ
Computer modelling of change in neurone membrane conductivity inducing generator potential
Computer modelling of change in neurone membrane conductivity inducing generator potential
1988
Biophysics
1988
1988
Biophysics
V.33 № 6, 1066-1071
V.33 № 6, 1066-1071
Abstract
Abstract
АННОТАЦИЯ
АННОТАЦИЯ
It has been established that injection of cAMP produces in snail neurones a generator potential associated with increase in the sodium and decrease in potassium permeability of the external membrane of the neurone. A model is proposed allowing for diffusion of cAMP within the neurone from the site of injection and the interaction of these molecules with the intracellular system controlling the permeability of the external membrane. The resulting generation of impulses gives a current of calcium ions across the external membrane. The model allows for calcium diffusion towards cAMP and its influence on the speed of work of the enzyme destroying cAMP. The agreement of the results of calculation of the ionic
current I(t) with the experiment makes it possible to determine the parameters of the model and calculate the observed change in the distribution in time of the nerve impulses when the effect of the entry of calcium is crucial.
It has been established that injection of cAMP produces in snail neurones a generator potential associated with increase in the sodium and decrease in potassium permeability of the external membrane of the neurone. A model is proposed allowing for diffusion of cAMP within the neurone from the site of injection and the interaction of these molecules with the intracellular system controlling the permeability of the external membrane. The resulting generation of impulses gives a current of calcium ions across the external membrane. The model allows for calcium diffusion towards cAMP and its influence on the speed of work of the enzyme destroying cAMP. The agreement of the results of calculation of the ionic
current I(t) with the experiment makes it possible to determine the parameters of the model and calculate the observed change in the distribution in time of the nerve impulses when the effect of the entry of calcium is crucial.
chaimatics
Chaimatics
Discovery of links between the biology, physics and mathematics, and founding a new area of studies focused on computations in living systems are his life achievements. Efim Liberman gave the name of “Chaimatics” to this new area of science
I
DNA is the text of a code written for molecular computers of living cells. The notion of “Text” is intrinsically opposite to a random sequence of symbols, and it can exist only inside the system of language. In this case, it is a genetic language, which is isomorphic to a natural language
II
Computations conducted in a living cell are real physical actions, and free energy and time must be spent for completing them. As all living organisms are comprised of cells, this statement is applicable to any control processes implemented in the biosphere
III
Molecular computations are limited by the microscopic scale of a cell and inevitable impact of the computations on formulation of a problem begin solved. The Chaimatics grew from the recognition of the computation reality as the quantum mechanics grew from the recognition of the measurement reality.
IV
A cell creates а quantum computing tool for solving complex problems. This tool utilizes hypersound quanta, and uses the cell cytoskeleton as the computing environment. In such a computer, a price of elementary computation converges to the physical limit, which is Planck’s constant
Chaimatic's statements are simple, but they require a change in the traditional vision, rooted in scientific practice
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Chapter I
The journey of life in science
chaimatics
хаиматика
хаиматика
Итогом жизни в науке стало установление связей между биологией, физикой, математикой и новая область исследования, посвященная вычислениям в живых системах. Ефим Либерман дал имя новой науке: «Хаиматика»
I
ДНК – это текст программы для молекулярных компьютеров клеток. «Текст» по определению не случайная последовательность знаков и может существовать только внутри языковой системы. В данном случае это генетический язык, изоморфный естественному языку
II
Вычисление в живой клетке является реальным физическим действием и требует затрат свободной энергии и времени. Поскольку все живые организмы состоят из клеток, это относится ко всему управлению, которое осуществляется в биосфере
III
Молекулярные вычисления ограничены микроскопическим объемом клетки и принципиальной возможностью влияния вычисления на условия решаемой задачи: квантовая механика возникла из осознания реальности измерения, Хаиматика - из реальности вычисления
IV
Для решения сложных задач клетка создает устройство квантового вычисления, использующего кванты гиперзвука и клеточный цитоскелет, как вычисляющую среду. Цена вычисления в таком компьютере стремится к физическому пределу – постоянной Планка
Утверждения Хаиматики просты, но они требуют изменения традиционных представлений, принятых в научной практике
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Глава I
Как все начиналось
хаиматика