Publications
ПУБЛИКАЦИИ
Intraneurone processing of information. Delayed change of the membrane potential after administrations of cyclic nucleotides.
Intraneurone processing of information. Delayed change of the membrane potential after administrations of cyclic nucleotides.
1985
Biophysics
1985
1985
Biophysics
V. 30, № 3, 498-503
V. 30, № 3, 498-503
Abstract
Abstract
АННОТАЦИЯ
АННОТАЦИЯ
Depolarization of the neurone membrane induced by cyclic adenosine monophosphate (cAMP) has been demonstrated both by the method of ionophoresis and pressure injection. Inflation of the neurone at the moment of injection of different substances under pressure causes depolarization of the membrane with much the same time course as injection of cAMP. The influence of cAMP with use of pressure may be isolated by introducing small volumes of concentrated solutions. The similarity of the effects of cAMP and mechanical stimulation of the neurone suggest that in both cases the action is mediated by the electromechanical system consisting of the microskeleton and micro muscles controlling permeability of the molecular channels. The delay in the effect after the moment of introducing cAMP and cGMP is slight which suggests their direct interaction with the cytoskeleton.
Depolarization of the neurone membrane induced by cyclic adenosine monophosphate (cAMP) has been demonstrated both by the method of ionophoresis and pressure injection. Inflation of the neurone at the moment of injection of different substances under pressure causes depolarization of the membrane with much the same time course as injection of cAMP. The influence of cAMP with use of pressure may be isolated by introducing small volumes of concentrated solutions. The similarity of the effects of cAMP and mechanical stimulation of the neurone suggest that in both cases the action is mediated by the electromechanical system consisting of the microskeleton and micro muscles controlling permeability of the molecular channels. The delay in the effect after the moment of introducing cAMP and cGMP is slight which suggests their direct interaction with the cytoskeleton.
chaimatics
Chaimatics
Discovery of links between the biology, physics and mathematics, and founding a new area of studies focused on computations in living systems are his life achievements. Efim Liberman gave the name of “Chaimatics” to this new area of science
I
DNA is the text of a code written for molecular computers of living cells. The notion of “Text” is intrinsically opposite to a random sequence of symbols, and it can exist only inside the system of language. In this case, it is a genetic language, which is isomorphic to a natural language
II
Computations conducted in a living cell are real physical actions, and free energy and time must be spent for completing them. As all living organisms are comprised of cells, this statement is applicable to any control processes implemented in the biosphere
III
Molecular computations are limited by the microscopic scale of a cell and inevitable impact of the computations on formulation of a problem begin solved. The Chaimatics grew from the recognition of the computation reality as the quantum mechanics grew from the recognition of the measurement reality.
IV
A cell creates а quantum computing tool for solving complex problems. This tool utilizes hypersound quanta, and uses the cell cytoskeleton as the computing environment. In such a computer, a price of elementary computation converges to the physical limit, which is Planck’s constant
Chaimatic's statements are simple, but they require a change in the traditional vision, rooted in scientific practice
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Chapter I
The journey of life in science
chaimatics
хаиматика
хаиматика
Итогом жизни в науке стало установление связей между биологией, физикой, математикой и новая область исследования, посвященная вычислениям в живых системах. Ефим Либерман дал имя новой науке: «Хаиматика»
I
ДНК – это текст программы для молекулярных компьютеров клеток. «Текст» по определению не случайная последовательность знаков и может существовать только внутри языковой системы. В данном случае это генетический язык, изоморфный естественному языку
II
Вычисление в живой клетке является реальным физическим действием и требует затрат свободной энергии и времени. Поскольку все живые организмы состоят из клеток, это относится ко всему управлению, которое осуществляется в биосфере
III
Молекулярные вычисления ограничены микроскопическим объемом клетки и принципиальной возможностью влияния вычисления на условия решаемой задачи: квантовая механика возникла из осознания реальности измерения, Хаиматика - из реальности вычисления
IV
Для решения сложных задач клетка создает устройство квантового вычисления, использующего кванты гиперзвука и клеточный цитоскелет, как вычисляющую среду. Цена вычисления в таком компьютере стремится к физическому пределу – постоянной Планка
Утверждения Хаиматики просты, но они требуют изменения традиционных представлений, принятых в научной практике
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Глава I
Как все начиналось
хаиматика